Boil 1 litre of fresh tap water. Allow boiled water to cool for no more than 30 minutes. Do not use artificially softened or repeatedly boiled water. Do not add extra powder or water to make the feeds stronger or weaker and do not press powder into scoop. Using too much or too little powder can make your baby ill. Over time, people with SMA experience progressive muscle weakness and loss of muscle control. Potential complications include: Koletzko et al Lower Protein in infant formula is associated with lower weight up to 2y: a randomized clinical trial. Am J Clin Nutr 2009; 89: 1836–45.

Type 3 (mild): Symptoms of type 3 SMA (also called Kugelbert-Welander or juvenile-onset SMA) appear after a child’s first 18 months of life. Some people with type 3 don’t have signs of disease until early adulthood. Type 3 symptoms include mild muscle weakness, difficulty walking and frequent respiratory infections. Over time, symptoms can affect the ability to walk or stand. Type 3 SMA doesn’t significantly shorten life expectancy. Genetic test: This blood test identifies problems with the SMN1 gene. As a diagnostic tool, a genetic test is 95% effective at finding the altered SMN1 gene. Some states test for SMA as part of routine newborn screenings.This is in line with Article 7 of the International Code of Marketing of Breast-milk Substitutes (the WHO Code), which clearly sets out the ways in which formula companies and healthcare professionals can work together. We know that today's babies don't just rely on their parents to look after them now, but they also need all of us to help look after the world they inherit from us. That's why we use forever recyclable steel tins. Making it super easy to do your bit even when sleep deprived. And now at least 66% of the plastic in the lid & scoop is produced from sugar cane, which is a renewable plant-based resource.

It is the only Growing Up Milk in the UK and Ireland to contain the latest scientific breakthrough in formula, 2’FL and LNnT. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2015). Vitamin C and contribution to the normal function of the immune system: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal, 13(11), 4298. Approx. age of baby: 2 - 4 weeks; Approx. weight of baby: 3.7 kg, 8 lb; Preparation for single feeds: Level scoops: 4, Cooled, freshly boiled water: 120 ml, fl. oz. (approx.): 4, Feeds in 24 hours: 6

Boil 1 litre of fresh tap water. Allow boiled water to cool for no more than 30 minutes. Measure 180 ml (approx. 6 fl. oz.) of water into a beaker or bottle, carefully - the water is hot. Do not use artificially softened or repeatedly boiled water. Pull the safety seal and open the lid. Lift the tab, pull on the foil seal, carefully and safely remove the seal and dispose of it. Jantscher-Krenn E, Bode L. Human milk oligosaccharides and their potential benefits for the breast-fed neonate. Minerva Pediatr. 2012 Feb;64(1):83-99. At SMA® Nutrition, nature inspires us everyday. We have continued to be at the forefront of baby nutrition research for Disease-modifying therapy: These drugs stimulate production of SMN protein. Nusinersen (Spinraza®) is FDA approved for both children and adults. Your provider injects the drug into the space around the spinal canal. A different medication, risdaplam (Evrysdi®), helps adults and children older than two months. People take risdaplam daily by mouth (orally).

Approx. age of baby: 4 months; Approx. weight of baby: 6.7 kg, 14 3/4 lb; Preparation for single feeds: Level scoops: 6, Cooled, freshly boiled water: 180 ml, fl. oz. (approx.): 6, Feeds in 24 hours: 5 SMA® ADVANCED Follow-on Milk which is tailored for babies from 6 months as part of a varied weaning diet. It is the only follow-on formula in the UK and Ireland to contain 2’FL and LNnT. SMA® ADVANCED also contains Zinc and Vitamins A, C & D to help support the normal function of baby’s immune system, and is enriched with Iron for normal cognitive development in baby’s brain.Bosheva, M., Tokodi, I., Krasnow, A., Pedersen, H. K., Lukjancenko, O., Eklund, A. C., Grathwohl, D., Sprenger, N., Berger, B., Cercamondi, C. I., & 5 HMO Study Investigator Consortium (2022). Infant Formula With a Specific Blend of Five Human Milk Oligosaccharides Drives the Gut Microbiota Development and Improves Gut Maturation Markers: A Randomized Controlled Trial. Frontiers in nutrition, 9, 920362. https://doi.org/10.3389/fnut.2022.920362 Approx. age of baby: 6 months; Approx. weight of baby: 7.6 kg, 16 3/4 lb; Preparation for single feeds: Level scoops: 8, Cooled, freshly boiled water: 240 ml, fl. oz. (approx.): 8, Feeds in 24 hours: 4

We also believe that we have a responsibility to share information about our products, and the science behind them, with HCPs. We believe that this should be done in such a way as to minimise and manage any potential conflicts of interest. Approx. age of baby: 3 months; Approx. weight of baby: 6.1 kg, 13 1/2 lb; Preparation for single feeds: Level scoops: 6, Cooled, freshly boiled water: 180 ml, fl. oz. (approx.): 6, Feeds in 24 hours: 5Gene replacement therapy: Children younger than two may benefit from a one-time intravenous (IV) infusion of a drug called onasemnogene abeparvovec-xioi (Zolgensma®). This therapy replaces a missing or faulty SMN1 gene with a functioning gene. Whilst this product is made under strict hygienic conditions, it is not sterile. Failure to follow instructions on preparation and storage may make your baby ill. For example, Article 7.5 requires that HCPs disclose to their employer if they are sponsored by formula company to attend a conference. In doing so, it makes it clear that it is not against the Code to accept such sponsorship. Nestlé’s policy on the Sponsorship of Health Workers and Institutions for Professional Development and Scientific Research also requires that HCPs disclose any sponsorship to their employer.