As a result of this the person’s mobility is made easier as there is little to no pain, swelling, or stiffness in the legs. An esvs Journal study conducted in 2011 found that AS195 led to an improvement in the clinical profile of patients with CVI, and that swelling and pain in the leg were significantly reduced.

In terms of safety and tolerance, red vine leaf extract proved good or satisfactory, which was expected from a flavonoid-rich natural product. Natural remedies for heavy, tired legs, water retention and cellulite In some cases, taking pure vine leaf extracts has been shown to cause gastrointestinal discomforts. However, in most cases these discomforts are relieved naturally within a short time. The phytonutrients present in its leaves act as natural venotonics, angioprotectors and anti-edematous. In other words, they contribute to the tonicity and protection of blood vessels and capillaries. They are particularly capable of reducing the permeability of blood vessels and improving their resistance. Therefore, a red vine treatment may be of interest to combat venous insufficiency, to alleviate the sensation of heavy and / or swollen legs, among other benefits. Several natural supplements are used for CVI which can help relieve symptoms of the condition, including centella asiatica/gotu kola extract, hesperidin, diosmin, butcher’s broom extract, escin/horse chestnut extract and red vine leaf extract among others.The extract contains a number of bioflavonoids including flavone/flavonol glycosides and glucuronides, in particular quercetin-3-O-b-D-glucuronide, isoquercitrin and kaempferol-3-glucoside. It is registered as an over-the-counter medicine in several European countries. What evidence is available for its use? In theory and at high doses, the red vine could reduce the action of classic anticoagulant or antiplatelet treatments. Antioxidants in red vine leaves help protect cells and DNA from damage buildup caused by free radicals and prevent them from altering normal cell activity that could turn regular cells into cancerous ones. Free radical damage buildup, known as oxidative stress, causes extensive inflammation which is a risk factor for chronic disease. A 2012 Japanese study revealed that red vine leaves extract holds anti-inflammatory effects and may contribute to reducing liver damage. Our red vine leaves are harvested when its nutrient content is at its highest; the leaves are then dried and its nutrients extracted using precise temperature controls and purified water, guaranteeing a grapevine extract of the highest quality. Each tablet contains 360mg of natural red vine leaf extract - equivalent to 5,400mg of fresh red vine leaf - including 40% polyphenols, the key ingredient. Take daily for at least six weeks to start seeing the full benefits.

According to research, red vine leaves owe all of their health effect to their antioxidant content. Antioxidants found in red vine leaves include flavonoids (quercetin-3-O-beta-D-glucuronide, isoquercetin, myricetin, kaempferol), catechins, epicatechins, anthocyanins, procyanidins and proanthocyanidins. Other famous antioxidant compounds in the leaves include resveratrol, also found in grapes and grape wine, and viniferin, the main bioactive constituent in grapevine sap. ( Phytopharmacy: An evidence-based guide to herbal medicinal products). Researchers next assessed the best dose in a 12-week study involving 257 men and women with mild to moderate chronic venous insufficiency. One group took 360mg red vine leaf extracts per day, one took 720mg daily, while another took placebo.

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Red vine leaves have also been said to be heart friendly. By improving blood circulation in the body, the leaves decrease the chances of cardiovascular diseases. The treatment is provided with advanced protocols based on the Physics of radiofrequency and ultrasound and on the anatomy and physiology of cellulite and skin laxity Symptoms of chronic venous insufficiency include feelings of heaviness, aching legs, swelling of the ankles or calves, sensations of tension in the legs and pain. The overlying skin may become dry and discoloured and acquires a characteristic mottled pigmentation. The placebo group demonstrated an increase in lower leg volume at six weeks and at 12 weeks. Patients treated with red vine leaf extract AS 195 showed a decrease in mean volume compared with the control group. The results of changes in ankle circumference were similarly positive, with reductions in the active treatment groups but little change in the placebo group. All patients in the active treatment groups had subjective improvements in symptoms at six weeks, and the changes were significantly greater after 12 weeks. In addition, red vine leaf extract improved skin microcirculation and transcutaneous oxygen pressure - ideal for cellulite prevention and reduction.