With Ayyub's support, they sacked Jerusalem in the summer of 1244, leaving it in ruins and useless to both Christians and Muslims.

Plans for a new crusade to be led by Frederick came to nothing, and Frederick himself was excommunicated by Gregory IX again in 1239. It lasted for almost two hundred years, from the accession of Godfrey of Bouillon in 1099 until the fall of Acre in 1291.In June 1258, Philip and the Hospitallers marched on Acre while a Genoese fleet attacked the city by sea. Henry, Amalric, Otton, and Jean escaped, as did a young Templar named Roger de Flor, but most of the other defenders did not, including the master of the Templars Guillaume de Beaujeu. He said that he was later released, but not before being told he was banned from the Old City for the rest of the day. The First Crusade was preached at the Council of Clermont in 1095 by Pope Urban II, with the goal of assisting the Byzantine Empire against the invasions of the " Turks and Arabs" and "to destroy this vile race from the lands of our friends.

The arrival of the crusade was a brief respite from the Lombard War; Filangieri remained in Tyre and did not participate. In 1256 the commercial rivalry between the Venetian and Genoese merchant colonies broke out into open warfare.

Aimery had already inherited Cyprus from Guy, and had been crowned king by Frederick Barbarossa's son, Emperor Henry VI.