However, the downside to peanuts is that they contain a lot of fat – so it's unlikely that you’d eat them all in one sitting. A daily dose varies depending on what you’re being treated for – typically, it’s 2 to 8g per day but can be higher. For example, for chest pain due to coronary artery disease, the dosage has been determined as 3 to 6g three times per day for one month. Know the overdose risks Citrulline or l-citrulline is closely related to l-arginine. For starters, it’s also an amino acid. It was isolated by Japanese scientists Koga and Odake in 1914 from watermelon juice. In fact, its name is from the Latin word for watermelon, Citrullus lanatus (x). Bai, Y., Sun, L., Yang, T., Sun, K., Chen, J., and Hui, R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials. Am J Clin.Nutr. 2009;89(1):77-84. View abstract.

L-arginine might increase potassium levels in the body. Some "water pills" might also increase potassium in the body. Taking L-arginine along with some "water pills" might cause too much potassium to be in the body. Erectile dysfunction (ED). Taking 2.5-5 grams of L-arginine by mouth daily seems to improve sexual function in people with ED. Taking L-arginine with medications such as sildenafil and tadalafil might work better than taking either L-arginine or the medication alone. This is largely thanks to its relationship to an increase in human growth hormone (the production of which drops off as we age), which helps us recover from workouts, improves strength, and enhances libido and muscle growth. 4 Although there are risks that correlate with L-arginine use, most research indicates it is safe for most people in small doses. However, the FDA does not monitor the safety or effectiveness of supplements, so it is important to choose a reputable brand that undertakes third-party testing. On the other hand, food consumption alone may not provide enough L-arginine to meet a person’s needs. Therefore, individuals should discuss their options with a doctor before changing their diet.Individuals with clogged arteries can take 28 grams of the supplement in equal increments about 3 to 4 times a day. Due to its ability to ease blood vessels, some people may take a l-arginine supplement to improve their cardiovascular health. Davis, J. S. and Anstey, N. M. Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med. 2011;39(2):380-385. View abstract. While this is rare, in the cases it does occur it is often within older adults or people with medical conditions that need attention. Other names for l-arginine

For example, studies investigating the effects of L-arginine on blood pressure have used doses of 6–30 grams per day for 2–24 weeks ( 22, 23). Be cautious with this combination • Medications for high blood pressure (Antihypertensive drugs) interacts with L-ARGININE Fazelian, S., et al. (2014). Effects of l-arginine supplementation on antioxidant status and body composition in obese patients with pre-diabetes: A randomized controlled clinical trial. Camarena Pulido, E. E., et al. (2016). Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial [Abstract].High blood pressure. Taking L-arginine by mouth can reduce blood pressure in healthy people, people with high blood pressure, and people with slightly high blood pressure with or without diabetes. Khalifah, R. A., et al. (2015). The shortened combined clonidine and arginine test for growth hormone deficiency is practical and specific: A diagnostic accuracy study. Cereda, E., Gini, A., Pedrolli, C., and Vanotti, A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. J Am Geriatr.Soc 2009;57(8):1395-1402. View abstract. Improving athletic performance: The results of a 2020 study suggest that L-arginine supplements may have a positive effect on aerobic and anaerobic exercise performance.

High blood pressure during pregnancy. Some studies show that L-arginine infusions may lower blood pressure in pregnant women who develop high blood pressure. The most frequent adverse effects of overdosing on l-arginine include bloating, diarrhea, abdominal pain, gout, airway inflammation, low blood pressure, and more.https://www.semanticscholar.org/paper/Promising-effects-of-arginine-enriched-oral-on-Schols/9b0324d1ac7446329a4b8afaaa5c08252abc1940